Human Gene Set: GSE3691_CONVENTIONAL_VS_PLASMACYTOID_DC_SPLEEN_DN


Standard name GSE3691_CONVENTIONAL_VS_PLASMACYTOID_DC_SPLEEN_DN
Systematic name M6368
Brief description Genes down-regulated in dendiritic cells from speen: conventional versus plasmacytoid.
Full description or abstract To characterize differences between BALB/c splenic CD11cintB220+Gr1+ PDCs (plasmacytoid dendritic cells), CD11cintB220+CD49b+ IKDCs (interferon producing killer-dendritic cells), and CD11chighB220- cDCs (conventional dendritic cells), we performed gene expression profile analysis using Affymetrix chips. We FACS-sorted BALB/c spleen DC subpopulations. Comparison of differentially expressed genes between IKDCs and cDCs vividly revealed selective expression of multiple NK-related genes in IKDCs . These included granzymes A, B, K and M, perforin, Fas ligand, and NK receptors such as NKG2A, NKG2D, Ly49 family genes, NKR-P1, NKG7, NKp46 and Mafa (KLRG1). No NK-related genes were highly expressed in the PDCs.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 16444266   Authors: Chan CW,Crafton E,Fan HN,Flook J,Yoshimura K,Skarica M,Brockstedt D,Dubensky TW,Stins MF,Lanier LL,Pardoll DM,Housseau F
Exact source GSE3691_2657_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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