Human Gene Set: GSE36009_WT_VS_NLRP10_KO_DC_UP


Standard name GSE36009_WT_VS_NLRP10_KO_DC_UP
Systematic name M8775
Brief description Genes up-regulated in dendritic cells: wildtype versus NLRP10 [GeneID=338322] knockout.
Full description or abstract Nlrp10-deficient mice have a profound defect in helper T cell-driven immune responses. T cell priming is impaired due to a defect in the emigration of a dendritic cells from inflamed tissue and antigen transport to draining lymph nodes. DC chemotaxis to CCR7-dependent and independent ligands is intact in the absence of Nlrp10. Therefore to identify novel molecules potentially involved in Nlrp10-dependent DC function we used an unbiased gene array approach on Nlrp10-deficient BMDCs treated with or without LPS.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 22538615   Authors: Eisenbarth SC,Williams A,Colegio OR,Meng H,Strowig T,Rongvaux A,Henao-Mejia J,Thaiss CA,Joly S,Gonzalez DG,Xu L,Zenewicz LA,Haberman AM,Elinav E,Kleinstein SH,Sutterwala FS,Flavell RA
Exact source GSE36009_2672_200_UP
Related gene sets (show 7 additional gene sets from the source publication)

(show 89 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 200 genes
Gene families ? Categorize these 200 genes by gene family
Show members (show 200 source identifiers mapped to 200 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

See MSigDB license terms here. Please note that certain gene sets have special access terms.