Human Gene Set: GSE3400_UNTREATED_VS_IFNB_TREATED_MEF_DN
Standard name
GSE3400_UNTREATED_VS_IFNB_TREATED_MEF_DN
Systematic name
M6134
Brief description
Genes down-regulated in mouse embryonic fibroblasts (MEF): untreated versus interferon beta.
Full description or abstract
A number of IFN-induced proteins are believed to be responsible for the antiviral state induced by IFNs. Our microarray analysis of IFN-regulated genes in MEFs from wild-type mice identified 124 probe sets that were differentially regulated upon IFN treatment. This group consisted of many known ISGs such as Ifit1, Gbp2, mx1, Isg15, Stat1, nmi, mx2, If204, Adar, Irf1, and protein kinase R.
