Human Gene Set: GSE32901_TH17_EMRICHED_VS_TH17_NEG_CD4_TCELL_UP


Standard name GSE32901_TH17_EMRICHED_VS_TH17_NEG_CD4_TCELL_UP
Systematic name M8929
Brief description Genes up-regulated in CD4 [GeneID=920] Th17 T cells: enriched versus negative.
Full description or abstract In this study, we examined differential gene expression in naïve human CD4+ T cells, as well as in effector Th1, Th17-negative and Th17-enriched CD4- T cell subsets. We observed a marked enrichment for increased gene expression in effector CD4+ T cells compared to naive CD4+ among immune-mediated disease oci genes. Within effector T cells, expression of disease-associated genes was increased in Th17-enriched compared to Th17-negative cells. We used microarray to examine the gene expresssion profile and level of human naïve, Th1 and effector T cell subsets.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 22715389   Authors: Zhang W,Ferguson J,Ng SM,Hui K,Goh G,Lin A,Esplugues E,Flavell RA,Abraham C,Zhao H,Cho JH
Exact source GSE32901_3357_200_UP
Related gene sets (show 11 additional gene sets from the source publication)

(show 75 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 128 genes
Gene families ? Categorize these 128 genes by gene family
Show members (show 200 source identifiers mapped to 128 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.


Creative Commons Attribution 4.0 International License (CC-BY-4.0)

The contents of this gene set are protected by copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California, subject to the terms and conditions of the Creative Commons Attribution 4.0 International License.

See the full MSigDB license terms here.