Human Gene Set: GSE29614_DAY3_VS_DAY7_TIV_FLU_VACCINE_PBMC_DN
Standard name
GSE29614_DAY3_VS_DAY7_TIV_FLU_VACCINE_PBMC_DN
Systematic name
M4915
Brief description
Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee at day 3 post-vaccination versus those at day 7 post-vaccination.
Full description or abstract
Systems vaccinology has emerged as an interdisciplinary field that combines systems wide measurements and network and predictive modeling applied to vaccinology. Here we used the systems vaccinology approach to study the molecular mechanisms underlying the innate responses to the trivalent inactivated influenza (TIV) and live attenuated influenza (LAIV) vaccination in humans, and to identify early gene signatures that predict the magnitude of the antibody responses to influenza vaccination.
