Human Gene Set: GSE29614_CTRL_VS_DAY3_TIV_FLU_VACCINE_PBMC_DN
Standard name
GSE29614_CTRL_VS_DAY3_TIV_FLU_VACCINE_PBMC_DN
Systematic name
M4907
Brief description
Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those from day 3 post-vaccination.
Full description or abstract
Systems vaccinology has emerged as an interdisciplinary field that combines systems wide measurements and network and predictive modeling applied to vaccinology. Here we used the systems vaccinology approach to study the molecular mechanisms underlying the innate responses to the trivalent inactivated influenza (TIV) and live attenuated influenza (LAIV) vaccination in humans, and to identify early gene signatures that predict the magnitude of the antibody responses to influenza vaccination.
