Human Gene Set: GSE28449_WT_VS_LRF_KO_GERMINAL_CENTER_BCELL_DN


Standard name GSE28449_WT_VS_LRF_KO_GERMINAL_CENTER_BCELL_DN
Systematic name M8346
Brief description Genes down-regulated in germinal center B lymphocytes: wildtype versus ZBTB7A [GeneID=51341] knockout.
Full description or abstract B cells are indispensable for humoral immunity, as they ultimately give rise to antibody-secreting plasma cells. During T cell-dependent antibody responses, naive B cells form germinal centers (GCs), a distinct histologic structure found in secondary lymphoid organs. Naive B cells become activated upon interaction with T cells and antigen presenting cells, and begin to rapidly proliferate and form the characteristic GC structure. To elucidate the overall effect of LRF loss in the GCB cell transcriptome, gene expression microarray analysis of FACS-sorted GCB cells was performed. LRF Flox/+ mb-1 Cre+ mice were used as a control to normalize the potential effects of Cre recombinase, and four RNA samples for each genotype were used for the analysis.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 21646720   Authors: Sakurai N,Maeda M,Lee SU,Ishikawa Y,Li M,Williams JC,Wang L,Su L,Suzuki M,Saito TI,Chiba S,Casola S,Yagita H,Teruya-Feldstein J,Tsuzuki S,Bhatia R,Maeda T
Exact source GSE28449_2448_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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