Human Gene Set: GSE27291_0H_VS_6H_STIM_GAMMADELTA_TCELL_DN
Standard name
GSE27291_0H_VS_6H_STIM_GAMMADELTA_TCELL_DN
Systematic name
M8453
Brief description
Genes down-regulated in gamma delta T cells activated by phophoantigen BrHPP and IL2 [GeneID=3558]: 0h versus 6h.
Full description or abstract
We used microarrays to detail the global programme of gene expression by circulating TCRVgamma9+ gamma delta T cells isolated from healthy individuals,tested either as resting cells or cells activated by phosphoantigen BrHPP and IL-2at an early(+6hrs) and a late (+7days) timepoint. We find that with more ?NK cell? genes than alphabeta T cells and more ?T cell? genes than NK cells, the circulating TCRVgamma9+ gamma delta T cells cells have a hybrid transcriptome. The gene signature of the activated cells recapitulates their physiological functions: Th1 cytokine, chemokine and cytotoxic activities at first and mitotic activity at later time points. The gene expression pattern of activated normal gamma delta T cells is nevertheless clearly distinctive from that of NK/T and peripheral T cell lymphomas of the gamma delta subtype.
