Human Gene Set: GSE24726_WT_VS_E2_2_KO_PDC_DN


Standard name GSE24726_WT_VS_E2_2_KO_PDC_DN
Systematic name M8061
Brief description Genes down-regulated in plasmacytoid dendritic cells: wildtype versus TCF4 [GeneID=6925] knockout.
Full description or abstract The interferon-producing plasmacytoid dendritic cells (PDC) share common progenitors with antigen-presenting classical dendritic cells (cDC), yet they possess distinct morphology and molecular features resembling those of lymphocytes. It is unclear whether the unique cell fate of PDC is actively maintained in the steady state. We report that the deletion of transcription factor E2-2 from mature peripheral PDC caused their spontaneous differentiation into cells with cDC properties. This included the loss of PDC markers, increase in MHC class II expression and T cell priming capacity, acquisition of dendritic morphology and induction of cDC signature genes. Genome-wide chromatin immunoprecipitation revealed direct binding of E2-2 to key PDC-specific and lymphoid genes, as well as to certain genes enriched in cDC. Thus, E2-2 actively maintains the cell fate of mature PDC and opposes the ?default? cDC fate, in part through direct regulation of lineage-specific gene expression programs.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 21145760   Authors: Ghosh HS,Cisse B,Bunin A,Lewis KL,Reizis B
Exact source GSE24726_2452_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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