Human Gene Set: GSE24634_NAIVE_CD4_TCELL_VS_DAY5_IL4_CONV_TREG_DN


Standard name GSE24634_NAIVE_CD4_TCELL_VS_DAY5_IL4_CONV_TREG_DN
Systematic name M4589
Brief description Genes down-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 5.
Full description or abstract CD25+ regulatory T cells develop in the thymus (nTregs), but may also be generated in the periphery upon stimulation of naive CD4 T cells under appropriate conditions (iTregs). The mechanisms that regulate the generation of peripheral iTregs are largely unknown. We used microarrays to gain insights into the molecular program of extrathymic Treg development.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 21347372   Authors: Prots I,Skapenko A,Lipsky PE,Schulze-Koops H
Exact source GSE24634_1438_200_DN
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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