Human Gene Set: GSE22282_HYPOXIA_VS_NORMOXIA_MYELOID_DC_DN


Standard name GSE22282_HYPOXIA_VS_NORMOXIA_MYELOID_DC_DN
Systematic name M8065
Brief description Genes down-regulated in myeloid dendritic cells: hypoxia versus normoxia.
Full description or abstract Dendritic cells (DCs) are professional antigen-presenting cells whose activity is intrinsically linked to the microenvironment. Hypoxia is a condition of low oxygen tension occurring in inflammatory tissues that creates a special microenvironment conditioning cell physiology. We studied the effects of hypoxia on the differentiation of human monocytes into DCs and maturation into mature DCs. Mature DCs were differentiated in vitro from human monocytes under normoxic or hypoxic conditions and the gene expression profile was determined.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 21148811   Authors: Bosco MC,Pierobon D,Blengio F,Raggi F,Vanni C,Gattorno M,Eva A,Novelli F,Cappello P,Giovarelli M,Varesio L
Exact source GSE22282_3498_200_DN
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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