Human Gene Set: GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_3H_UP
Standard name
GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_3H_UP
Systematic name
M8251
Brief description
Genes up-regulated in B lymphocytes: control versus stimulated by anti-IgM for 3h.
Full description or abstract
Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ flux and proliferation of splenic B cells, increased apoptosis and suppressed germinal centre formation and immunoglobulin class switch by T cell-independent antigens. By controlling IL-10 synthesis in B cells, NFATc1 supported the proliferation and IL-2 synthesis of T cells in vitro and appeared to contribute to the mild clinical course of Experimental Autoimmune Encephalomyelitis in mice bearing NFATc1-/- B cells. These data indicate NFATc1 as a key factor controlling B cell function.
