Human Gene Set: GSE19512_NAUTRAL_VS_INDUCED_TREG_UP


Standard name GSE19512_NAUTRAL_VS_INDUCED_TREG_UP
Systematic name M8361
Brief description Genes up-regulated in T reg: natural versus induced cells.
Full description or abstract The relative contribution of induced and natural Foxp3+ regulatory T cells (iTreg and nTreg cells, respectively) to the maintenance of tolerance is unknown. We examined their respective roles by in vivo adoptive transfer immunotherapy of newborn Foxp3-deficient BALB/c mice. Survival, weight gain, tissue infiltration, T cell activation, and the concentration of proinflammatory cytokines were used as outcome measurements. Treatment with iTreg cells alone was not successful. While effective in preventing death, treatment with nTreg cells alone was associated with chronic inflammation and autoimmunity. Outcomes markedly improved when conventional T (Tconv) cells were transferred together with the nTreg cells, where 10% of the peripheral Treg cell pool was derived by in-situ conversion. This enhancement depended upon the capacity of Tconv cells to express Foxp3. The gene expression profile of in vivo derived iTreg cells was similar to the established nTreg cell genetic signature. These results identify iTreg cells as an essential regulatory subset that supplements tolerance maintained by nTreg cells.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 21723159   Authors: Haribhai D,Williams JB,Jia S,Nickerson D,Schmitt EG,Edwards B,Ziegelbauer J,Yassai M,Li SH,Relland LM,Wise PM,Chen A,Zheng YQ,Simpson PM,Gorski J,Salzman NH,Hessner MJ,Chatila TA,Williams CB
Exact source GSE19512_2400_200_UP
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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