Human Gene Set: GSE18148_CBFB_KO_VS_WT_TREG_UP


Standard name GSE18148_CBFB_KO_VS_WT_TREG_UP
Systematic name M4251
Brief description Genes up-regualted in comparison of regulatory T cell (Treg) from CBFB [GeneID=865] deficient mice versus those from wild type animals.
Full description or abstract Gene expression profiles of Cbfb-deficient and control Treg cells were compared. Naturally arising regulatory T (Treg) cells express the transcription factor FoxP3, which critically controls the development and function of Treg cells. FoxP3 interacts with another transcription factor Runx1 (also known as AML1). Here we showed that Treg cell-specific deficiency of Cbf?, a cofactor for all Runx proteins, or that of Runx1, but not Runx3, induced lymphoproliferation, autoimmune disease, and hyper-production of IgE. Cbfb-deleted Treg cells exhibited impaired suppressive function in vitro and in vivo, with altered gene expression profiles including attenuated expression of FoxP3 and high expression of interleukin-4. The Runx complex bound to more than 3000 gene loci in Treg cells, including the Foxp3 regulatory regions and the Il4 silencer. In addition, knockdown of RUNX1 showed that RUNX1 is required for the optimal regulation of FoxP3 expression in human T cells. Taken together, our results indicate that the Runx1-Cbf? heterodimer is indispensable for in vivo Treg cell function, in particular, suppressive activity and optimal expression of FoxP3.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 19800266   Authors: Kitoh A,Ono M,Naoe Y,Ohkura N,Yamaguchi T,Yaguchi H,Kitabayashi I,Tsukada T,Nomura T,Miyachi Y,Taniuchi I,Sakaguchi S
Exact source GSE18148_1212_200_UP
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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