Human Gene Set: GSE16266_LPS_VS_HEATSHOCK_AND_LPS_STIM_MEF_DN


Standard name GSE16266_LPS_VS_HEATSHOCK_AND_LPS_STIM_MEF_DN
Systematic name M7217
Brief description Genes down-regulated in mouse embryonic fibroblasts (MEF): LPS versus LPS and heat shock.
Full description or abstract To clarify inflammatory genes whose expression is suppressed at high temperatures, we performed comprehensive analysis of gene expression by using a DNA microarray. Two independent primary cultures of mouse embryo fibroblasts (MEF1 and MEF2) were treated with LPS for 4 hours, or treated with LPS for 4 hours after the pretreatment with heat shock at 42?C for 1 hour, and we identified 100 genes that undergo more than a 3-fold increase with LPS treatment. Remarkably, 86 genes (86%) underwent less than a 2-fold increase after combined treatments with heat shock and LPS in MEF1 and MEF2 cells.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 20018623   Authors: Takii R,Inouye S,Fujimoto M,Nakamura T,Shinkawa T,Prakasam R,Tan K,Hayashida N,Ichikawa H,Hai T,Nakai A
Exact source GSE16266_3080_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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