Human Gene Set: GSE15735_2H_VS_12H_HDAC_INHIBITOR_TREATED_CD4_TCELL_DN


Standard name GSE15735_2H_VS_12H_HDAC_INHIBITOR_TREATED_CD4_TCELL_DN
Systematic name M7162
Brief description Genes down-regulated in CD4 [GeneID=920] T cells treated with HDAC inhibitors: 2h versus 12h.
Full description or abstract Histone acetyltransferases (HATs) and deacetylases (HDACs) function antagonistically to control histone acetylation. As acetylation is a histone mark for active transcription, HATs have been associated with active and HDACs with inactive genes. We describe here genome-wide mapping of HATs and HDACs binding on chromatin and ?nd that both are found at active genes with acetylated histones. Our data provide evidence that HATs and HDACs are both targeted to transcribed regions of active genes by phosphorylated RNA Pol II. Furthermore, the majority of HDACs in the human genome function to reset chromatin by removing acetylation at active genes. Inactive genes that are primed by MLL-mediated histone H3K4 methylation are subject to a dynamic cycle of acetylation and deacetylation by transient HAT/HDAC binding, preventing Pol II from binding to these genes but poising them for future activation. Silent genes without any H3K4 methylation signal show no evidence of being bound by HDACs.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 19698979   Authors: Wang Z,Zang C,Cui K,Schones DE,Barski A,Peng W,Zhao K
Exact source GSE15735_2250_200_DN
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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