Human Gene Set: GSE15624_3H_VS_6H_HALOFUGINONE_TREATED_CD4_TCELL_DN


Standard name GSE15624_3H_VS_6H_HALOFUGINONE_TREATED_CD4_TCELL_DN
Systematic name M7109
Brief description Genes down-regulated in CD4 [GeneID=920] T cells treated with halofuginone [PubChem=400772]: 3h versus 6h.
Full description or abstract T cell differentiation to the Th17 effector subset requires stimulation through the T cell and co-stimulatory receptors, together with cytokine stimulation by TGFb and IL-6. The small molecule halofuginone (HF) inhibits Th17 cell development and induces a pattern of stress-regulated gene expression that mimics amino acid starvation. We used global transcript profiling to ask how halofuginone modulates gene expression induced during T cell activaiton and Th17 differentiation
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 19498172   Authors: Sundrud MS,Koralov SB,Feuerer M,Calado DP,Kozhaya AE,Rhule-Smith A,Lefebvre RE,Unutmaz D,Mazitschek R,Waldner H,Whitman M,Keller T,Rao A
Exact source GSE15624_2677_200_DN
Related gene sets (show 5 additional gene sets from the source publication)

(show 148 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 147 genes
Gene families ? Categorize these 147 genes by gene family
Show members (show 200 source identifiers mapped to 147 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

See MSigDB license terms here. Please note that certain gene sets have special access terms.