Human Gene Set: GSE12392_WT_VS_IFNAR_KO_CD8A_NEG_SPLEEN_DC_DN


Standard name GSE12392_WT_VS_IFNAR_KO_CD8A_NEG_SPLEEN_DC_DN
Systematic name M7139
Brief description Genes down-regulated in CD8A- [GeneID=925] splenic dendritic cells: wildtype versus IFNAR1 [GeneID=3454] knockout mice.
Full description or abstract Type I Interferons encompasses a large family of closely related cytokines comprising of at least 13 IFN-? isotypes and single IFN-?. Both IFN-? and IFN-? exert their activity through a common receptor IFNAR. Type I Interferons have broad regulatory effects and various subtypes of dendritic cells are influenced by this cytokines. In our study we asked question whether the low, constitutive levels of type I Interferons produced under steady state conditions are important for proper function of splenic conventional dendritic cells.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 19581626   Authors: Zietara N,?yszkiewicz M,Gekara N,Pucha?ka J,Dos Santos VA,Hunt CR,Pandita TK,Lienenklaus S,Weiss S
Exact source GSE12392_2739_200_DN
Related gene sets (show 11 additional gene sets from the source publication)

(show 36 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 198 genes
Gene families ? Categorize these 198 genes by gene family
Show members (show 200 source identifiers mapped to 198 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

See MSigDB license terms here. Please note that certain gene sets have special access terms.