Human Gene Set: GOMF_TRANSCRIPTION_COREPRESSOR_ACTIVITY

For the Mouse gene set with the same name, see GOMF_TRANSCRIPTION_COREPRESSOR_ACTIVITY

Standard name GOMF_TRANSCRIPTION_COREPRESSOR_ACTIVITY
Systematic name M19029
Brief description A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:MF: GO Molecular Function
Source publication  
Exact source GO:0003714
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0003714
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
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Version history 2026.1.Hs: Updated to GO Release 2025-10-10.


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