Human Gene Set: GOMF_GENERAL_TRANSCRIPTION_INITIATION_FACTOR_ACTIVITY

For the Mouse gene set with the same name, see GOMF_GENERAL_TRANSCRIPTION_INITIATION_FACTOR_ACTIVITY

Standard name GOMF_GENERAL_TRANSCRIPTION_INITIATION_FACTOR_ACTIVITY
Systematic name M26860
Brief description A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary. [GOC:txnOH-2018]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:MF: GO Molecular Function
Source publication  
Exact source GO:0140223
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0140223
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 2026.1.Hs: Updated to GO Release 2025-10-10.


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