Human Gene Set: GOCC_TORC2_COMPLEX
For the Mouse gene set with the same name, see GOCC_TORC2_COMPLEX
Standard name
GOCC_TORC2_COMPLEX
Systematic name
M46938
Brief description
A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p. [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787]
Full description or abstract
Collection
C5: Ontology GO: Gene Ontology GO:CC: GO Cellular Component
Source publication
Exact source
GO:0031932
Related gene sets
External links
http://amigo.geneontology.org/amigo/term/GO:0031932
Filtered by similarity ?
Source species
Homo sapiens
Contributed by
Gene Ontology (Gene Ontology Consortium)
Source platform or identifier namespace
Human_NCBI_Gene_ID
Dataset references
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Human tissue compendium (Novartis)
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NCI-60 cell lines (National Cancer Institute)
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these 9 genes
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9 genes by gene family
Show members
(show 9 source identifiers mapped to 9 genes)
Source Id
NCBI (Entrez) Gene Id
Gene Symbol
Gene Description
143686
143686
SESN3
sestrin 3 [Source:HGNC Symbol;Acc:HGNC:23060]
2475
2475
MTOR
mechanistic target of rapamycin kinase [Sou...
253260
253260
RICTOR
RPTOR independent companion of MTOR complex...
55615
55615
PRR5
proline rich 5 [Source:HGNC Symbol;Acc:HGNC...
64223
64223
MLST8
MTOR associated protein, LST8 homolog [Sour...
79109
79109
MAPKAP1
MAPK associated protein 1 [Source:HGNC Symb...
79899
79899
PRR5L
proline rich 5 like [Source:HGNC Symbol;Acc...
83667
83667
SESN2
sestrin 2 [Source:HGNC Symbol;Acc:HGNC:20746]
9675
9675
TTI1
TELO2 interacting protein 1 [Source:HGNC Sy...
Version history
2024.1.Hs: Updated to GO Release 2024-04-24.
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