Human Gene Set: GOCC_RNA_N6_METHYLADENOSINE_METHYLTRANSFERASE_COMPLEX
For the Mouse gene set with the same name, see GOCC_RNA_N6_METHYLADENOSINE_METHYLTRANSFERASE_COMPLEX
Standard name
GOCC_RNA_N6_METHYLADENOSINE_METHYLTRANSFERASE_COMPLEX
Systematic name
M45313
Brief description
A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B). [GOC:dgf, GOC:sp, PMID:22685417, PMID:24316715, PMID:24407421, PMID:29507755, PMID:29535189, PMID:29547716]
Full description or abstract
Collection
C5: Ontology GO: Gene Ontology GO:CC: GO Cellular Component
Source publication
Exact source
GO:0036396
Related gene sets
External links
http://amigo.geneontology.org/amigo/term/GO:0036396
Filtered by similarity ?
Source species
Homo sapiens
Contributed by
Gene Ontology (Gene Ontology Consortium)
Source platform or identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format: grp | gmt | xml | json | TSV metadata
Compute overlaps ?
(show collections to investigate for overlap with this gene set)
Compendia expression profiles ?
NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds )
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 9 genes
Gene families ?
Categorize these
9 genes by gene family
Show members
(show 9 source identifiers mapped to 9 genes)
Source Id
NCBI (Entrez) Gene Id
Gene Symbol
Gene Description
23091
23091
ZC3H13
zinc finger CCCH-type containing 13 [Source:H...
25962
25962
VIRMA
vir like m6A methyltransferase associated [So...
29890
29890
RBM15B
RNA binding motif protein 15B [Source:HGNC Sy...
56339
56339
METTL3
methyltransferase 3, N6-adenosine-methyltrans...
57721
57721
METTL14
methyltransferase 14, N6-adenosine-methyltran...
64783
64783
RBM15
RNA binding motif protein 15 [Source:HGNC Sym...
64863
64863
METTL4
methyltransferase 4, N6-adenosine [Source:HGN...
79872
79872
CBLL1
Cbl proto-oncogene like 1 [Source:HGNC Symbol...
9589
9589
WTAP
WT1 associated protein [Source:HGNC Symbol;Ac...
Version history
2024.1.Hs: Updated to GO Release 2024-04-24.
See MSigDB license terms here . Please note that certain gene sets
have special access terms.