Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms. [GOC:bhm, PMID:23229515]
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Collection
C5: Ontology GO: Gene Ontology GO:CC: GO Cellular Component