The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8. [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]
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C5: Ontology GO: Gene Ontology GO:CC: GO Cellular Component