Human Gene Set: GOCC_ALPHA_KETOACID_DEHYDROGENASE_COMPLEX

For the Mouse gene set with the same name, see GOCC_ALPHA_KETOACID_DEHYDROGENASE_COMPLEX

Standard name GOCC_ALPHA_KETOACID_DEHYDROGENASE_COMPLEX
Systematic name M25860
Brief description A multi-enzyme complex that catalyzes the oxidative decarboxylation of an alpha-ketoacid - pyruvate, a branched-chain alpha-ketoacid or alpha-ketoglutarate (also known as 2-oxoglutarate). The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: a dihydrolipoyl transacylase (E2) forms the core of the complex, with an alpha-ketoacid dehydrogenase (E1) and a dihydrolipoamide dehydrogenase (E3) attached through non-covalent bonds. The E1 and E2 components are specific to different alpha-ketoacid dehydrogenase complexes, whereas the E3 component is the same. Additional proteins may also be present. [GOC:mah, PMID:10745006]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:CC: GO Cellular Component
Source publication  
Exact source GO:0045240
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0045240
Filtered by similarity ?
Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 16 genes
Gene families ? Categorize these 16 genes by gene family
Show members (show 16 source identifiers mapped to 16 genes)
Version history 2024.1.Hs: Renamed from GOCC_DIHYDROLIPOYL_DEHYDROGENASE_COMPLEX. Updated to GO Release 2024-04-24.

See MSigDB license terms here. Please note that certain gene sets have special access terms.