Human Gene Set: GOBP_SPHINGOSINE_1_PHOSPHATE_RECEPTOR_SIGNALING_PATHWAY
For the Mouse gene set with the same name, see GOBP_SPHINGOSINE_1_PHOSPHATE_RECEPTOR_SIGNALING_PATHWAY
Standard name
GOBP_SPHINGOSINE_1_PHOSPHATE_RECEPTOR_SIGNALING_PATHWAY
Systematic name
M45062
Brief description
A G protein-coupled receptor signaling pathway initiated by sphingosine-1-phosphate binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ascb_2009, GOC:signaling, PMID:14592418, PMID:22001186, Reactome:R-HSA-419428]
Full description or abstract
Collection
C5: Ontology GO: Gene Ontology GO:BP: GO Biological Process
Source publication
Exact source
GO:0003376
Related gene sets
External links
http://amigo.geneontology.org/amigo/term/GO:0003376
Filtered by similarity ?
Source species
Homo sapiens
Contributed by
Gene Ontology (Gene Ontology Consortium)
Source platform or identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format: grp | gmt | xml | json | TSV metadata
Compute overlaps ?
(show collections to investigate for overlap with this gene set)
Compendia expression profiles ?
NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds )
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 15 genes
Gene families ?
Categorize these
15 genes by gene family
Show members
(show 15 source identifiers mapped to 15 genes)
Source Id
NCBI (Entrez) Gene Id
Gene Symbol
Gene Description
124976
124976
SPNS2
SPNS lysolipid transporter 2, sphingosine-1-...
1901
1901
S1PR1
sphingosine-1-phosphate receptor 1 [Source:H...
1903
1903
S1PR3
sphingosine-1-phosphate receptor 3 [Source:H...
207
207
AKT1
AKT serine/threonine kinase 1 [Source:HGNC S...
2830
2830
GPR6
G protein-coupled receptor 6 [Source:HGNC Sy...
388931
388931
MFSD2B
MFSD2 lysolipid transporter B, sphingolipid ...
5291
5291
PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kina...
5294
5294
PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kina...
53637
53637
S1PR5
sphingosine-1-phosphate receptor 5 [Source:H...
56848
56848
SPHK2
sphingosine kinase 2 [Source:HGNC Symbol;Acc...
5879
5879
RAC1
Rac family small GTPase 1 [Source:HGNC Symbo...
7430
7430
EZR
ezrin [Source:HGNC Symbol;Acc:HGNC:12691]
8698
8698
S1PR4
sphingosine-1-phosphate receptor 4 [Source:H...
8877
8877
SPHK1
sphingosine kinase 1 [Source:HGNC Symbol;Acc...
9294
9294
S1PR2
sphingosine-1-phosphate receptor 2 [Source:H...
Version history
2024.1.Hs: Updated to GO Release 2024-04-24.
See MSigDB license terms here . Please note that certain gene sets
have special access terms.