Human Gene Set: GOBP_RNA_POLYMERASE_II_PREINITIATION_COMPLEX_ASSEMBLY


Standard name GOBP_RNA_POLYMERASE_II_PREINITIATION_COMPLEX_ASSEMBLY
Systematic name M23951
Brief description The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA. [GOC:txnOH, PMID:15020047, PMID:31300188]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0051123
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0051123
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
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Version history 2024.1.Hs: Updated to GO Release 2024-04-24.

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