Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex. [GOC:dph, GOC:sdb_2009, GOC:tb, PMID:32189388]
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C5: Ontology GO: Gene Ontology GO:BP: GO Biological Process