Human Gene Set: GOBP_NON_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION

For the Mouse gene set with the same name, see GOBP_NON_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION

Standard name GOBP_NON_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION
Systematic name M13738
Brief description An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF). [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0038061
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0038061
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
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Version history 2024.1.Hs: Updated to GO Release 2024-04-24.

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