Human Gene Set: GOBP_INTEGRATED_STRESS_RESPONSE_SIGNALING

For the Mouse gene set with the same name, see GOBP_INTEGRATED_STRESS_RESPONSE_SIGNALING

Standard name GOBP_INTEGRATED_STRESS_RESPONSE_SIGNALING
Systematic name M40536
Brief description The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. [PMID:27629041]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0140467
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0140467
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
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Version history 2025.1.Hs: Updated to GO Release 2025-03-16.


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