Human Gene Set: GOBP_HIPPO_SIGNALING

For the Mouse gene set with the same name, see GOBP_HIPPO_SIGNALING

Standard name GOBP_HIPPO_SIGNALING
Systematic name M11445
Brief description An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation. [PMID:17318211, PMID:18328423, PMID:36347846]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0035329
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0035329
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
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Version history 2025.1.Hs: Updated to GO Release 2025-03-16.


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