Human Gene Set: GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY


Standard name GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY
Systematic name M2280
Brief description The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0007186
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0007186
Filtered by similarity ?
Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 1321 genes
Gene families ? Categorize these 1321 genes by gene family
Show members (show 1324 source identifiers mapped to 1321 genes)
Version history 2024.1.Hs: Updated to GO Release 2024-04-24.

See MSigDB license terms here. Please note that certain gene sets have special access terms.