Human Gene Set: GOBP_ERK1_AND_ERK2_CASCADE

For the Mouse gene set with the same name, see GOBP_ERK1_AND_ERK2_CASCADE

Standard name GOBP_ERK1_AND_ERK2_CASCADE
Systematic name M16677
Brief description A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development. [PMID:20811974, PMID:23125017, PMID:28903453]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0070371
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0070371
Filtered by similarity ? (show 1 similar ontology term(s) from the external resource)
Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
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GTEx compendium
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Version history 2025.1.Hs: Updated to GO Release 2025-03-16.


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