Human Gene Set: GOBP_CORNIFICATION

For the Mouse gene set with the same name, see GOBP_CORNIFICATION

Standard name GOBP_CORNIFICATION
Systematic name M24369
Brief description A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability). [GOC:krc, PMID:18846107]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0070268
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0070268
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 2025.1.Hs: Updated to GO Release 2025-03-16.


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