Human Gene Set: GLASS_IGF2BP1_CLIP_TARGETS_KNOCKDOWN_DN


Standard name GLASS_IGF2BP1_CLIP_TARGETS_KNOCKDOWN_DN
Systematic name M42507
Brief description Transcripts bound to IGF2BP1 and consistently downregulated upon IGF2BP1 knockdown in various cancer derived cell lines.
Full description or abstract The oncofetal IGF2 mRNA-binding protein 1 (IGF2BP1) promotes tumor progression in a variety of solid tumors and its expression is associated with adverse prognosis. The main role proposed for IGF2BP1 in cancer cells is the stabilization of mRNAs encoding pro-oncogenic factors. This set contains 117 genes, consistently downregulated upon the knockdown of IGF2BP1 in various cancer derived cell lines. Furthermore, these 117 genes showed a positive correlation in RNA expression with IGF2BP1 in the majority of TCGA tumor cohorts and their transcripts were identified as direct IGF2BP1 targets by CLIP-seq experiments.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 33829040   Authors: Glaß M,Misiak D,Bley N,Müller S,Hagemann S,Busch B,Rausch A,Hüttelmaier S
Exact source Table 3S: DPPs, samples_with_CLIP_sites > 0
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Source species Homo sapiens
Contributed by Markus Glaß (Martin Luther University Halle-Wittenberg)
Source platform or
identifier namespace		 Human_Ensembl_Gene_ID
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NCI-60 cell lines (National Cancer Institute)

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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 7.5: First Introduced.

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