Human Gene Set: GKCGCNNNNNNNTGAYG_UNKNOWN


Standard name GKCGCNNNNNNNTGAYG_UNKNOWN
Systematic name M2826
Brief description Genes having at least one occurrence of the highly conserved motif M19 GKCGCNNNNNNNTGAYG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb]. The motif does not match any known transcription factor binding site.
Full description or abstract Comprehensive identification of all functional elements encoded in the human genome is a fundamental need in biomedical research. Here, we present a comparative analysis of the human, mouse, rat and dog genomes to create a systematic catalogue of common regulatory motifs in promoters and 3' untranslated regions (3' UTRs). The promoter analysis yields 174 candidate motifs, including most previously known transcription-factor binding sites and 105 new motifs. The 3'-UTR analysis yields 106 motifs likely to be involved in post-transcriptional regulation. Nearly one-half are associated with microRNAs (miRNAs), leading to the discovery of many new miRNA genes and their likely target genes. Our results suggest that previous estimates of the number of human miRNA genes were low, and that miRNAs regulate at least 20% of human genes. The overall results provide a systematic view of gene regulation in the human, which will be refined as additional mammalian genomes become available.
Collection C3: Regulatory Target
      TFT: Transcription Factor Targets
            TFT:TFT_LEGACY: TFT_Legacy
Source publication Pubmed 15735639   Authors: Xie X,Lu J,Kulbokas EJ,Golub TR,Mootha V,Lindblad-Toh K,Lander ES,Kellis M
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Source species Homo sapiens
Contributed by Xiaohui Xie (Broad Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.1: Moved to TFT_Legacy sub-collection.

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