Human Gene Set: GAVISH_3CA_MALIGNANT_METAPROGRAM_23_SECRETED_2


Standard name GAVISH_3CA_MALIGNANT_METAPROGRAM_23_SECRETED_2
Systematic name M46589
Brief description Genes upregulated in subsets of cells of a given type within various tumors
Full description or abstract In this study, an extensive analysis was conducted to define meta-programs (MPs) capturing intra-tumor heterogeneity across a spectrum of tumor types. The approach utilized non-negative matrix factorization (NMF) to analyze each cell type separately within individual tumor samples. This involved the analysis of malignant cells, macrophages, fibroblasts, endothelial cells, epithelial cells, T-cells, and B-cells. NMF was executed with varying parameter values (K=4, 5, 6, 7, 8, 9), thereby generating 39 programs for each cell type per sample. Each NMF program was summarized by the top 50 genes based on NMF coefficients.\nRobust MPs were then delineated for each cell type using a set of stringent criteria, including recurrence within the same tumor, similarity to programs in other tumors, and non-redundancy within a tumor. Subsequently, these robust NMF programs were clustered (per cell type) based on Jaccard similarity, leading to the identification of MPs associated with each cell type.\nTo enhance the quality of the MPs, a refinement steps were undertaken, involving the removal of MPs suspected of reflecting low-quality data (with an overrepresentation of ribosomal proteins or mitochondrial-encoded genes), single-study inclusion, or similarity to miss-annotated cell types.
Collection C4: Computational
      3CA: Curated Cancer Cell Atlas gene sets
Source publication Pubmed 37258682   Authors: Gavish A,Tyler M,Greenwald AC,Hoefflin R,Simkin D,Tschernichovsky R,Galili Darnell N,Somech E,Barbolin C,Antman T,Kovarsky D,Barrett T,Gonzalez Castro LN,Halder D,Chanoch-Myers R,Laffy J,Mints M,Wider A,Tal R,Spitzer A,Hara T,Raitses-Gurevich M,Stossel C,Golan T,Tirosh A,Suvā ML,Puram SV,Tirosh I
Exact source 3CA Download meta_programs_2023-07-13: Malignant. 23 Secreted II
Related gene sets (show 147 additional gene sets from the source publication)

(show 2 gene sets from the same authors)
External links https://www.weizmann.ac.il/sites/3CA/
Filtered by similarity ?
Source species Homo sapiens
Contributed by Itay Tirosh (Weizmann Institute of Science)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 50 genes
Gene families ? Categorize these 50 genes by gene family
Show members (show 50 source identifiers mapped to 50 genes)
Version history 2024.1.Hs: Renamed from GAVISH_3CA_MALIGNANT_METAPROGRAM_22_SECRETED_1.

See MSigDB license terms here. Please note that certain gene sets have special access terms.