Human Gene Set: GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_60DY_DN


Standard name GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_60DY_DN
Systematic name M41001
Brief description Genes down-regulated in peripheral blood mononuclear cell 60d vs 0d in unknown after exposure to YF-Vax/Stamaril , time point 60D
Full description or abstract Correlates of immune-mediated protection to most viral and cancer vaccines are still unknown. This impedes the development of novel vaccines to incurable diseases such as HIV and cancer. In this study, we have used functional genomics and polychromatic flow cytometry to define the signature of the immune response to the yellow fever (YF) vaccine 17D (YF17D) in a cohort of 40 volunteers followed for up to 1 yr after vaccination. We show that immunization with YF17D leads to an integrated immune response that includes several effector arms of innate immunity, including complement, the inflammasome, and interferons, as well as adaptive immunity as shown by an early T cell response followed by a brisk and variable B cell response. Development of these responses is preceded, as demonstrated in three independent vaccination trials and in a novel in vitro system of primary immune responses (modular immune in vitro construct [MIMIC] system), by the coordinated up-regulation of transcripts for specific transcription factors, including STAT1, IRF7, and ETS2, which are upstream of the different effector arms of the immune response. These results clearly show that the immune response to a strong vaccine is preceded by coordinated induction of master transcription factors that lead to the development of a broad, polyfunctional, and persistent immune response that integrates all effector cells of the immune system.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 19047440   Authors: Gaucher D,Therrien R,Kettaf N,Angermann BR,Boucher G,Filali-Mouhim A,Moser JM,Mehta RS,Drake DR 3rd,Castro E,Akondy R,Rinfret A,Yassine-Diab B,Said EA,Chouikh Y,Cameron MJ,Clum R,Kelvin D,Somogyi R,Greller LD,Balderas RS,Wilkinson P,Pantaleo G,Tartaglia J,Haddad EK,Sékaly RP
Exact source Supplemental Document 1
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External links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605227/bin/jem.20082292_1.pdf
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Source species Homo sapiens
Contributed by HIPC SIGNATURES (NIAID/HIPC SIGNATURES)
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identifier namespace		 HUMAN_GENE_SYMBOL
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