Human Gene Set: GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_10DY_UP


Standard name GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_10DY_UP
Systematic name M41141
Brief description Genes up-regulated in peripheral blood mononuclear cell 10d vs 0d in unknown after exposure to YF-Vax/Stamaril , time point 10D
Full description or abstract Correlates of immune-mediated protection to most viral and cancer vaccines are still unknown. This impedes the development of novel vaccines to incurable diseases such as HIV and cancer. In this study, we have used functional genomics and polychromatic flow cytometry to define the signature of the immune response to the yellow fever (YF) vaccine 17D (YF17D) in a cohort of 40 volunteers followed for up to 1 yr after vaccination. We show that immunization with YF17D leads to an integrated immune response that includes several effector arms of innate immunity, including complement, the inflammasome, and interferons, as well as adaptive immunity as shown by an early T cell response followed by a brisk and variable B cell response. Development of these responses is preceded, as demonstrated in three independent vaccination trials and in a novel in vitro system of primary immune responses (modular immune in vitro construct [MIMIC] system), by the coordinated up-regulation of transcripts for specific transcription factors, including STAT1, IRF7, and ETS2, which are upstream of the different effector arms of the immune response. These results clearly show that the immune response to a strong vaccine is preceded by coordinated induction of master transcription factors that lead to the development of a broad, polyfunctional, and persistent immune response that integrates all effector cells of the immune system.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 19047440   Authors: Gaucher D,Therrien R,Kettaf N,Angermann BR,Boucher G,Filali-Mouhim A,Moser JM,Mehta RS,Drake DR 3rd,Castro E,Akondy R,Rinfret A,Yassine-Diab B,Said EA,Chouikh Y,Cameron MJ,Clum R,Kelvin D,Somogyi R,Greller LD,Balderas RS,Wilkinson P,Pantaleo G,Tartaglia J,Haddad EK,Sékaly RP
Exact source Supplemental Document 1
Related gene sets (show 11 additional gene sets from the source publication)

(show 7 gene sets from the same authors)
External links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605227/bin/jem.20082292_1.pdf
Filtered by similarity ?
Source species Homo sapiens
Contributed by HIPC SIGNATURES (NIAID/HIPC SIGNATURES)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 196 genes
Gene families ? Categorize these 196 genes by gene family
Show members (show 196 source identifiers mapped to 196 genes)
Version history 7.3: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.