Human Gene Set: FONG_MCMASTER_OPA1_CARDIOPROTECTION_UP


Standard name FONG_MCMASTER_OPA1_CARDIOPROTECTION_UP
Systematic name M50229
Brief description Positive DEGs ( 8 > median log2 FC > 1.5, FDR < 0.01) with a partial least squares discriminant analysis (PLS-DA) VIP score >2 and Tuning Relief feature importance >0.2
Full description or abstract This gene set is derived from human left ventricle transcriptomes in the GTEx database stratified into high and low OPA1 expression quintiles. The set members represent the intersection of highly significant upregulated genes identified through differential expression analysis (DEA) and those selected as predictive features by Partial Least Squares-Discriminant Analysis (PLS-DA) and Tuned ReliefF (TuRF). The resulting consensus signatures were validated in a mouse model of pressure overload induced by transverse aortic constriction (TAC) to evaluate their association with preserved cardiac function and metabolic signaling.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 41366320   Authors: Fong-McMaster C,Pulente SM,Kennedy LS,Smith TKT,Myers S,Kanaan MN,Karam CY,Cope M,Levesque MM,McIlroy E,Lorenzen-Schmidt I,Goergen CJ,Fullerton MD,Cuperlovic-Culf M,Mulvihill EE,Harper ME
Exact source Supplementary Material 2 (12872_2025_5413_MOESM2_ESM), Overlapping Genes, Positive DEGs, Overlap = True
Related gene sets (show 1 additional gene sets from the source publication)
External links https://link.springer.com/article/10.1186/s12872-025-05413-0
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Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
Source platform or
identifier namespace		 Human_Ensembl_Gene_ID
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 2026.1.Hs: First Introduced.


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