Human Gene Set: FIGUEROA_AML_METHYLATION_CLUSTER_5_UP
Standard name
FIGUEROA_AML_METHYLATION_CLUSTER_5_UP
Systematic name
M2172
Brief description
Cluster 5 of aberrantly hypermethylated genes in blasts from AML (acute myeloid leukemia) patients.
Full description or abstract
We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which reflect critical biological differences. We therefore examined the methylation profiles of 344 patients with acute myeloid leukemia (AML). Clustering of these patients by methylation data segregated patients into 16 groups. Five of these groups defined new AML subtypes that shared no other known feature. In addition, DNA methylation profiles segregated patients with CEBPA aberrations from other subtypes of leukemia, defined four epigenetically distinct forms of AML with NPM1 mutations, and showed that established AML1-ETO, CBFb-MYH11, and PML-RARA leukemia entities are associated with specific methylation profiles. We report a 15 gene methylation classifier predictive of overall survival in an independent patient cohort (p < 0.001, adjusted for known covariates).
Collection
C2: Curated CGP: Chemical and Genetic Perturbations
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