Human Gene Set: FIGUEROA_AML_METHYLATION_CLUSTER_5_DN


Standard name FIGUEROA_AML_METHYLATION_CLUSTER_5_DN
Systematic name M2174
Brief description Cluster 5 of aberrantly hypomethylated genes in blasts from AML (acute myeloid leukemia) patients.
Full description or abstract We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which reflect critical biological differences. We therefore examined the methylation profiles of 344 patients with acute myeloid leukemia (AML). Clustering of these patients by methylation data segregated patients into 16 groups. Five of these groups defined new AML subtypes that shared no other known feature. In addition, DNA methylation profiles segregated patients with CEBPA aberrations from other subtypes of leukemia, defined four epigenetically distinct forms of AML with NPM1 mutations, and showed that established AML1-ETO, CBFb-MYH11, and PML-RARA leukemia entities are associated with specific methylation profiles. We report a 15 gene methylation classifier predictive of overall survival in an independent patient cohort (p < 0.001, adjusted for known covariates).
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 20060365   Authors: Figueroa ME,Lugthart S,Li Y,Erpelinck-Verschueren C,Deng X,Christos PJ,Schifano E,Booth J,van Putten W,Skrabanek L,Campagne F,Mazumdar M,Greally JM,Valk PJ,Löwenberg B,Delwel R,Melnick A
Exact source Table 3ES: Hypomethylated
Related gene sets (show 13 additional gene sets from the source publication)

(show 39 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 HUMAN_SEQ_ACCESSION
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 47 genes
Gene families ? Categorize these 47 genes by gene family
Show members (show 57 source identifiers mapped to 47 genes)
Version history 3.1: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.