Human Gene Set: EPPERT_LSC_R


Standard name EPPERT_LSC_R
Systematic name M19230
Brief description Genes up-regulated in functionally defined leukemic stem cells (LSC) from acute myeloid leukemia (AML) patients.
Full description or abstract Xenograft studies indicate that some solid tumors and leukemias are organized as cellular hierarchies sustained by cancer stem cells (CSCs). Despite the promise of the CSC model, its relevance in humans remains uncertain. Here we show that acute myeloid leukemia (AML) follows a CSC model on the basis of sorting multiple populations from each of 16 primary human AML samples and identifying which contain leukemia stem cells (LSCs) using a sensitive xenograft assay. Analysis of gene expression from all functionally validated populations yielded an LSC-specific signature. Similarly, a hematopoietic stem cell (HSC) gene signature was established. Bioinformatic analysis identified a core transcriptional program shared by LSCs and HSCs, revealing the molecular machinery underlying stemness properties. Both stem cell programs were highly significant independent predictors of patient survival and were found in existing prognostic signatures. Thus, determinants of stemness influence the clinical outcome of AML, establishing that LSCs are clinically relevant and not artifacts of xenotransplantation.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 21873988   Authors: Eppert K,Takenaka K,Lechman ER,Waldron L,Nilsson B,van Galen P,Metzeler KH,Poeppl A,Ling V,Beyene J,Canty AJ,Danska JS,Bohlander SK,Buske C,Minden MD,Golub TR,Jurisica I,Ebert BL,Dick JE
Exact source Supplemental Table 7
Related gene sets (show 3 additional gene sets from the source publication)

(show 275 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Kolja Eppert (McGill University)
Source platform or
identifier namespace		 AFFY_HG_U133
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 42 genes
Gene families ? Categorize these 42 genes by gene family
Show members (show 48 source identifiers mapped to 42 genes)
Version history 5.2: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.