Human Gene Set: EGFR_UP.V1_DN


Standard name EGFR_UP.V1_DN
Systematic name M2633
Brief description Genes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 [GeneID=2099] and engineered to express ligand-activatable EGFR [GeneID=1956].
Full description or abstract Profiling of MCF-7 cell lines stably overexpressing ligand-activatable EGFR as models of overexpressed growth factor signaling, as well as control vector transfected cells (coMCF-7) and control vector transfected cells long-term adapted for estrogen-independent growth (coMCF-7/lt-E2).
Collection C6: Oncogenic Signature
Source publication Pubmed 16585219   Authors: Creighton CJ,Hilger AM,Murthy S,Rae JM,Chinnaiyan AM,El-Ashry D
Exact source EGFR vs contol; bottom 200 genes (diff. of means)
Related gene sets (show 9 additional gene sets from the source publication)

(show 26 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 196 genes
Gene families ? Categorize these 196 genes by gene family
Show members (show 200 source identifiers mapped to 196 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.