Human Gene Set: DI_MARTINO_MATRISOME_HIGHLY_PROLIFERATIVE_HNSCC_TUMOR_CELL_DERIVED


Standard name DI_MARTINO_MATRISOME_HIGHLY_PROLIFERATIVE_HNSCC_TUMOR_CELL_DERIVED
Systematic name M47995
Brief description Tumor-cell-derived matrisome proteins detected exclusively in highly proliferative head-and-neck squamous cell carcinoma human-to-mouse xenografts (T-Hep3) compared to dormant head-and-neck squamous cell carcinoma human-to-mouse xenografts (D-Hep3).
Full description or abstract By using ECM proteomics we have defined the matrisome of dormant cancer cells vs proliferative cancer cells of head and neck squamous cell carcinoma (HNSCC). To do so, we used established cellular dormancy models and their proliferative counterparts: proliferative (T-HEp3) and dormant (D-HEp3) HNSCC. To investigate the matrisome composition of these dormant and proliferative tumors, we performed ECM-enriched mass spectrometry using decellularized T-HEp3 tumors and D-HEp3 dormant nodules grown in mice. Analysis of indolent D-HEp3 dormant nodules and aggressive T-HEp3 tumors grown in mice show a significant dysregulation of the matrisome signature. The human-in-mouse xenograft system used further allowed us to determine the relative contribution of tumor cells (human peptide sequences) and stromal cells (murine peptide sequences) to the production of the matrisome. This gene set lists the tumor-derived matrisome proteins detected exclusively in highly proliferative HNSCC human-to-mouse xenograft compared to dormant HNSCC human-to-mouse xenograft. We further excluded proteins that were detected in only one of the three proliferative samples.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 35121989   Authors: Di Martino JS,Nobre AR,Mondal C,Taha I,Farias EF,Fertig EJ,Naba A,Aguirre-Ghiso JA,Bravo-Cordero JJ
Exact source Supplemental Table S1 G
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External links https://doi.org/10.1038/s43018-021-00291-9
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Source species Homo sapiens
Contributed by Alexandra Naba (University of Illinois Chicago)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 2024.1.Hs: Renamed from DI_MARTINO_MATRISOME_HIGHLY_PROLIFERATIVE_HNSCC.

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