| Full description or abstract |
The gene expression program underlying the specification of human cell types is of fundamental interest. The study authors generated human cell atlases of gene expression and chromatin accessibility in fetal tissues. For gene expression, the study authors applied three-level combinatorial indexing to >110 samples representing 15 organs, ultimately profiling ~4 million single cells. The study authors leveraged the literature and other atlases to identify and annotate hundreds of cell types and subtypes, both within and across tissues. Our analyses focused on organ-specific specializations of broadly distributed cell types (such as blood, endothelial, and epithelial), sites of fetal erythropoiesis (which notably included the adrenal gland), and integration with mouse developmental atlases (such as conserved specification of blood cells). These data represent a rich resource for the exploration of in vivo human gene expression in diverse tissues and cell types. |
| Source publication |
Pubmed 33184181 Authors: Cao J,O'Day DR,Pliner HA,Kingsley PD,Deng M,Daza RM,Zager MA,Aldinger KA,Blecher-Gonen R,Zhang F,Spielmann M,Palis J,Doherty D,Steemers FJ,Glass IA,Trapnell C,Shendure J |
