Human Gene Set: DEMAGALHAES_AGING_DN


Standard name DEMAGALHAES_AGING_DN
Systematic name M2145
Brief description Genes consistently underexpressed with age, based on meta-analysis of microarray data.
Full description or abstract MOTIVATION: Numerous microarray studies of aging have been conducted, yet given the noisy nature of gene expression changes with age, elucidating the transcriptional features of aging and how these relate to physiological, biochemical and pathological changes remains a critical problem. RESULTS: We performed a meta-analysis of age-related gene expression profiles using 27 datasets from mice, rats and humans. Our results reveal several common signatures of aging, including 56 genes consistently overexpressed with age, the most significant of which was APOD, and 17 genes underexpressed with age. We characterized the biological processes associated with these signatures and found that age-related gene expression changes most notably involve an overexpression of inflammation and immune response genes and of genes associated with the lysosome. An underexpression of collagen genes and of genes associated with energy metabolism, particularly mitochondrial genes, as well as alterations in the expression of genes related to apoptosis, cell cycle and cellular senescence biomarkers, were also observed. By employing a new method that emphasizes sensitivity, our work further reveals previously unknown transcriptional changes with age in many genes, processes and functions. We suggest these molecular signatures reflect a combination of degenerative processes but also transcriptional responses to the process of aging. Overall, our results help to understand how transcriptional changes relate to the process of aging and could serve as targets for future studies. AVAILABILITY: http://genomics.senescence.info/uarrays/signatures.html. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 19189975   Authors: de Magalhćes JP,Curado J,Church GM
Exact source http://genomics.senescence.info/genes/microarray.php?show=4&sort=1&page=1 Underexpressed
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Source species Homo sapiens
Contributed by Joćo Pedro de Magalhaćes (University of Liverpool)
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identifier namespace		 Human_NCBI_Gene_ID
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Version history 3.1: First introduced

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