Human Gene Set: DANG_MYC_TARGETS_DN


Standard name DANG_MYC_TARGETS_DN
Systematic name M17557
Brief description Genes down-regulated by MYC [GeneID=4609] and whose promoters are bound by MYC, according to MYC Target Gene Database.
Full description or abstract We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 14519204   Authors: Zeller KI,Jegga AG,Aronow BJ,O'Donnell KA,Dang CV
Exact source http://www.myccancergene.org/site/mycTargetDB.asp
Related gene sets (show 4 additional gene sets from the source publication)

(show 15 gene sets from the same authors)
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Source species Homo sapiens
Contributed by Chi Dang (Johns Hopkins University)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
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Version history 3.0: First introduced

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