Human Gene Set: CYCLIN_D1_UP.V1_DN


Standard name CYCLIN_D1_UP.V1_DN
Systematic name M2652
Brief description Genes down-regulated in MCF-7 cells (breast cancer) over-expressing CCND1 [GeneID=595] gene.
Full description or abstract Here we describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene. Computational analysis of the expression patterns of thousands of genes across hundreds of tumor specimens suggested that a transcription factor, C/EBPbeta/Nf-Il6, participates in the consequences of cyclin D1 overexpression. Functional analyses confirmed the involvement of C/EBPbeta in the regulation of genes affected by cyclin D1 and established this protein as an indispensable effector of a potentially important facet of cyclin D1 biology. This work demonstrates that tumor gene expression databases can be used to study the function of a human oncogene in situ.
Collection C6: Oncogenic Signature
Source publication Pubmed 12914697   Authors: Lamb J,Ramaswamy S,Ford HL,Contreras B,Martinez RV,Kittrell FS,Zahnow CA,Patterson N,Golub TR,Ewen ME
Exact source cyclin D1 vs control; bottom 200 genes (diff-means)
Related gene sets (show 4 additional gene sets from the source publication)

(show 279 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 190 genes
Gene families ? Categorize these 190 genes by gene family
Show members (show 200 source identifiers mapped to 190 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.