Human Gene Set: CURSONS_NATURAL_KILLER_CELLS


Standard name CURSONS_NATURAL_KILLER_CELLS
Systematic name M45040
Brief description Genes up-regulated in natural killer cells.
Full description or abstract A preliminary gene set was obtained by combining the CIBERSORT (LM22) and Tosolini et al (LM7) gene sets for natural killer (NK) cells, together with a selection of marker genes from mouse NK cell studies (Huntington gene lists). Genes were filtered using by using bulk RNA-seq (GSE60424; via differential expression between NK cells and other sorted blood cell populations) and single cell RNA-seq (GSE72056; comparing various percentile thresholds between immune cell subsets) to select genes with particularly high transcript abundance within NK cells. The resulting gene set was further filtered to remove any genes which also show moderate-high expression within solid tumor cell lines from the Cancer Cell Line Encyclopedia. Genes filtered at various steps are labelled in Table S1 from the original publication (see EXTERNAL_DETAILS_URL). For a graphical summary please refer to Supplementary Figure S2 from DOI: 10.1158/2326-6066.CIR-18-0500
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 31088844   Authors: Cursons J,Souza-Fonseca-Guimaraes F,Foroutan M,Anderson A,Hollande F,Hediyeh-Zadeh S,Behren A,Huntington ND,Davis MJ
Exact source Supplementary Table 1 - Official gene symbols (HGNC) for our 20 NK signature genes and a subset of the results leading to their inclusion during curation, in particular bulk RNA-seq differential expression results and comparison to T cells for single-cell RNA-seq data from Tirosh et al (2016). For further details please refer to the Materials and Methods. LM22: CIBERSORT LM22 lists; LM7: Tosolini et al LM7 list.
Related gene sets (show 6 gene sets from the same authors)
External links https://cancerimmunolres.aacrjournals.org/highwire/filestream/37099/field_highwire_adju...
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Source species Homo sapiens
Contributed by Dharmesh D. Bhuva (Walter and Eliza Hall Institute of Medical Research)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 2022.1.Hs: First Introduced.

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